I-Curcumin

I-Turmeric isetyenziswe ngabantu phantse iminyaka engamawaka amane. Kangangamawaka eminyaka, ibisetyenziswa njengedayi, njengesiqholo sokupheka, nanjengento esetyenziswa kumayeza. Imibhalo yeSanskrit yokusetyenziswa kwayo njengesiqholo sibuyela kumaxesha amandulo aseIndiya. Igama elithi Turmeric livela kwiLatin Terra merita kuba iingcambu zayo, xa umhlaba, unegolide. I-spice yenziwe kwi-turmeric (i-Curcuma longa) isityalo kwintsapho yejinja. I-Turmeric ikhule ngenxa yeziqu zayo. Isiqu siyomiswa kwaye sigutywe sibe ngumgubo omthubi onencasa ekrakrayo eswiti esiyaziyo nesiyithandayo.

Isithako esiphambili se-turmeric esiye satsala ingqalelo yiCurcumin. Kukho iingxelo zokuthi i-curcumin-efana ne-polyphenols ineepropati ze-pharmaceutical, kubandakanywa ukunceda ukulawula iimpendulo ezivuthayo, izifo zamehlo eziphazamisayo, kunye nesifo se-metabolic syndrome. Iipolyphenols zizityalo zemetabolites ezinceda ukukhusela izityalo kwimitha ye-ultraviolet, izinambuzane, ibhaktheriya kunye neentsholongwane. Zikwangumthombo wokukrakra, ubumuncu, umbala, incasa, kunye namandla oxidizing.

Yintoni iipolyphenols

Iipolyphenols, ezifana ne-curcumin, ziye zafumana ukuthandwa ngenxa yokuba izifundo ze-epidemiological ziye zabonisa ngokuphindaphindiweyo ukuba ukutya okucebileyo kuzo kunokubonelela ngokukhululeka kokuvuvukala. Kwinqanaba lemolekyuli, iipolyphenols zinceda ukuzinzisa i-oxidation kumacandelo eselula. I-oxidation inokukhokelela kumonakalo kwii-organelles ngaphakathi kweeseli, kuquka i-mitochondria, "izindlu zamandla zeseli" apho amandla amaninzi eseli aveliswa yioksijini esiyiphefumlayo. Ukutya ukutya okune-antioxidant properties, ezifana namajikijolo, amantongomane, amafutha anempilo, kunye ne-turmeric, kucatshangelwa ukuba kukunceda ukugcina amanqanaba omonakalo we-oxidative.

Yiyiphi inzuzo i-curcumin enayo

Izifundo ezininzi eziphononongiweyo ziye zacebisa ukuba i-curcumin inokunceda ukunciphisa iimpawu zokuxinzezeleka kwe-oxidative egazini ngokuchaphazela umsebenzi wee-enzymes ezithintela ii-radicals zamahhala. Ukuphendula okuvuthayo kuluhlu olunzima lweempendulo kuyo nayiphi na izicubu ezisekelwe kwi-stimuli yangaphakathi okanye yangaphandle. Injongo kukukhusela izicubu kunye nokususa isizathu sokuqala somonakalo weseli. Nangona kunjalo, impendulo engapheliyo yokuvuvukala engalawulwayo ingakhokelela kumonakalo wezicubu ngaphandle kokulindela.

Ukuze kuveliswe le chain ye-chemical reactions, iimolekyuli zokubonisa ziveliswa kwaye zikhutshwe yiseli, ezikhokelela kwiimpendulo ezivuthayo kunye nomjikelezo oqhubekayo weeseli kunye neemolekyuli, oku kuthetha ukuba impendulo yokuvuvukala iba nzima kakhulu. Izifundo ezininzi zibonise ukuba i-curcumin ivimba le miqondiso yeselula, ngaloo ndlela inceda ukugcina inani leeprotheni zokuphendula ezivuthayo kunye neeseli. Nangona kunjalo, kuninzi lwezi zifundo, abaphandi baye bafumanisa ukuba i-curcumin ine-bioavailability embi.

Ngoko ke, emva kokuba i-curcumin ifakwe emzimbeni, kunzima ukuba i-gastrointestinal tract ithathe, idibanise kwaye isuse ngokukhawuleza emzimbeni. Ukutya i-curcumin ekutyeni okutyebileyo kwi-lecithin, njengamaqanda, ioyile yemifuno, kunye nebhotela, kunokuncedisa ukonyusa ukufunxa kwayo ngamathumbu. Izifundo ezidibanisa i-curcumin kunye ne-piperine, isithako sendalo se-pepper emnyama, ibonise ukuba ngenxa yokuba i-piperine inciphisa i-metabolism ye-curcumin, inyusa amanqanaba e-curcumin nge-20.

Ziziphi iziphumo zempendulo yokuvuvukala

Kubalulekile ukukhumbula ukuba impendulo yokuvuvukala yimpendulo yendalo yomzimba kwi-stimuli. Kukho iindidi ezimbini ezibanzi zeempendulo ezivuthayo. Impendulo ebukhali yokuvuvukala ihlala ixesha elifutshane kwaye ngokuqhelekileyo ibangelwa yi-stimulus yexeshana efana nebhaktheriya, intsholongwane, okanye ukulimala.

Nangona kunjalo, ukuba impendulo yokuvuvukala iyaqhubeka, impendulo yokuvuvukala iya kuhamba kwinqanaba lesibini. Eli nqanaba libizwa ngokuba yinqanaba elingapheliyo, kwaye ukuba lishiywe lingaqwalaselwa, lingakhokelela kwiintlobo zezifo ezingapheliyo. Ezinye iimpawu zempendulo yokudumba okungapheliyo azichanekanga kwaye zinokubandakanya iintlungu ezidibeneyo, iintlungu zomzimba, ukudinwa okungapheliyo, ukuphuthelwa, ukudakumba, kunye nokuzuza ubunzima okanye ukuncipha.

Iingxaki ezihlangeneyo - ngakumbi iingxaki zamathambo kunye nezidibeneyo - zicingelwa ukuba zidibene neempendulo ezingapheliyo ezivuthayo. Olunye uphando lubonisa ukuba isongezelelo semihla ngemihla ye-500 milligrams ukuya kwi-2 grams ye-curcumin inokuphucula intlungu yamadolo.

Nangona uphando aluzange lubonise ukuhla kwabamakishi bempendulo yokuvuvukala egazini, iziphumo zicingelwa ukuba zibangelwa iiprotheni ezivuthayo ezikhoyo kwindawo edibeneyo. Olunye uphononongo lubonise ukuba intlungu edibeneyo ithotyiwe kwiiyure ezimbini kunye ne-curcurin supplement kunye neyure enye kunye neyeza lokuphendula ukudumba kwe-nonsteroidal, ibuprofen, ichiza elicetyiswayo kwiingxaki ezidibeneyo. Ubude bexesha lokuxhaswa kwe-curcumin kwakuyi-4 kwiiveki ze-12.

I-Metabolic syndrome, ehambelana ngokusondeleyo nesifo se-glycometabolic type II, sesinye isifo esinokudibaniswa neempendulo ezivuthayo. Iqulethe uluhlu lweempawu, kubandakanywa ukumelana ne-insulin, amanqanaba aphezulu eswekile yegazi, uxinzelelo lwegazi oluphezulu, i-triglycerides ephakamileyo, i-HDL ephantsi, i-cholesterol "elungileyo", i-LDL ephezulu, i-cholesterol "embi" kunye nokukhuluphala. Izifundo ezininzi kwi-curcumin kunye nesifo se-metabolic zibonise ukuba i-curcumin inokwandisa uvakalelo lwe-insulin, ilawule uxinzelelo lwegazi, kunye namanqaku okuvuvukala.

Olunye uphando lubonise ukuba ukuxhaswa nge-1 gram ye-curcumin ngenyanga kuncitshiswe amanqanaba e-triglyceride, kodwa akukho tshintsho kwi-cholesterol okanye kumanqanaba amafutha emzimbeni. Uphononongo luye lwabonisa ukuba iimpendulo ezivuthayo, i-triglycerides ephezulu kunye ne-cholesterol ephezulu zonke zonyusa umngcipheko wesifo senhliziyo. I-Curcumin supplementation ikholelwa ukuba inceda ukunciphisa umngcipheko ohambelanayo.

Uyithatha njani i-curcumin

I-Curcumin kwi-curries i-avareji malunga ne-3% yesisindo esomileyo. Iiti kunye nezinye iziphuzo ze-con / aining turmeric, ezifana nobisi lwegolide, ezinye iindlela zokusela ezixhamla kwiipropati ezichasayo ze-curcumin. Njengekhari, umxholo wabo we-curcumin nawo uyahluka.

Izongezo zokutya ze-Curcumin eziqulethe i-curcumin ingcambu yengcambu yolunye uhlobo lwe-curcumin intake. Iilebula ezongezelelweyo ziya kubonisa iipesenti ezahlukeneyo ze-curcumin extract. Ukulawulwa komgangatho ozimeleyo kunye novavanyo lweelabhoratri zokuqinisekisa umgangatho kwaye uhlole imveliso ukuqinisekisa la mabango kunye nokuqinisekisa ileyibhile njengoko kuyalelwa ngumvelisi wemveliso. Ezinye i-curcumin dietary supplement formulations zinokuthi ziqulethe ezinye izicatshulwa, ezifana ne-pepper extract (ipayipi) okanye imixube yobunikazi equkethe iintsini zemifuno, okanye amanye amalungiselelo e-lipid, ekuzameni ukuphucula i-bioavailability ye-curcumin. Ngokukodwa, uphando lubonise ukuba i-curcumin ingasetyenziselwa njenge-agent ye-topical ekuqulunqweni kweefilimu ze-collagen, i-lotions, izipontshi kunye nama-bandages ukukhuthaza ulusu olunempilo.

Umthamo kunye nokuqinisekiswa kwezongezelelo ze-curcumin

I-Curcumin ivunyiwe yi-US Food and Drug Administration njenge-compounds epholileyo. Iidosi eziphakanyisiweyo zemihla ngemihla zivela kwi-3 mg / kg ukuya kwi-4-10 g / ngosuku. Ekubeni izifundo ezininzi ezisebenzisa i-extract zinomda weenyanga ze-1-3, ukuza kuthi ga ngoku, akukho bungqina bayo nayiphi na imiphumo yexesha elide ukusuka ekusebenziseni ixesha elide le-curcumin. Nangona kungakhange kubekho iingxelo zokusabela okubi kakhulu ekusebenziseni i-curcumin, ezinye iziphumo zecala zingabandakanya urhudo, intlungu yentloko, i-rashes yesikhumba, kunye nezitulo eziphuzi.

Ukuba uthatha amayeza, qhagamshelana nodokotela wakho ngaphambi kokuba ucinge ngokuqala izongezelelo ze-curcumin. Izifundo ze-in vitro zibonise ukuba i-curcumin yonyusa umngcipheko wokuphuma kwegazi kwizigulana ezithatha i-diluents ngaxeshanye, ngoko ke nayiphi na intsebenziswano yeziyobisi enokwenzeka okanye iinkxalabo kufuneka zixoxwe nogqirha wakho. Kukho neengxelo ze-curcumin powder ezibangela ukusabela okungahambi kakuhle ekufowuneni, njengokurhawuzelela okanye ukukhawuleza emva koqhagamshelwano.

Ukuba kukho nayiphi na kwezi mpawu, yeka ukusebenzisa ngokukhawuleza. Kubaluleke kakhulu ukuyeka ukusebenzisa nayiphi na imveliso equkethe i-curcumin kwaye ubize iinkonzo zongxamiseko zengingqi yakho ukuba uziva nakuphi na ukuphefumla, ukuphefumula okufutshane, ubunzima bokugwinya okanye ukuvuvukala komlomo.

Ngokubanzi, i-curcumin ibonisa amandla amakhulu njengenye into kwaye inokunceda ukugcina imisebenzi enempilo. Sisinongo esihle sokongeza incasa ehlaziyayo kunye nombala ekutyeni, ngakumbi inkukhu kunye nemifuno. Dibanisa amaqunube, inyama ebhityileyo, kunye namafutha asempilweni, kwaye ukutya kwakho kuya kuzala iipolyphenols.

Khumbula, ukuba ukhetha ukuqala ukuthatha nayiphi na isongezelelo sokutya, qiniseka ukuba udibane nodokotela wakho kwaye uqiniseke ukuba ufunda ileyibhile yemveliso ngokucacileyo kuqala ukugqiba inani le-curcumin eliza kusetyenziswa.